Specifically, Nuc-mediated disruption of NETs provokes the formation of deoxyadenosine monophosphate (dAMP) which is subsequently converted by AdsA into deoxyadenosine (dAdo), a potent deoxyribonucleoside that exquisitely kills macrophages during abscess formation by targeting the mammalian purine salvage pathway (26, 29). Here, NUCB1 is linked to abscess.