In fact, emerging literature suggests that two synergistically acting enzymes of staphylococci, secreted nuclease (Nuc) and the cell surface-attached 5’-3’-nucleotidase adenosine synthase A (AdsA), impede abscess entry of macrophages thereby exacerbating pathology scores and disease outcomes in mouse models of infectious disease (26, 27). The gene discussed is NUCB1; the disease is abscess.