CD274 and neoplasm: For this purpose, we employed a highly immunogenic (MOC1) (ICI sensitive) and poorly immunogenic (MOC2) (primary ICI resistant) syngeneic model of treatment naïve oral cavity cancer, in which we observed superior tumor responses and survival when combining ICI (anti-PD-L1 or anti-PD-1) with Ad5-CMV-mTNFα/mIL-2 (a murine version of TILT-123).