Indeed, this could explain the increase in tumor-specific antibodies observed in the anti-PD-L1 combination group, which were also indirectly shown to enhance NK-mediated ADCC and which might facilitate antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) or increase antigen presentation by antigen-presenting cells such as macrophages and dendritic cells (58). This evidence concerns the gene CD274 and neoplasm.