NOTCH1 and congenital bilateral aplasia of vas deferens from CFTR mutation: These differing roles of the Notch1 pathway in CAVD highlight that there are likely heterogenous pathophysiological pathways leading to clinical CAVD, and suggest that the mechanosensitive Notch1 pathway may be suppressed in congenitally predisposed CAVD, while being accentuated in LPS-induced chronic inflammation.