Wang et al. utilised multi-omic screening of explanted human aortic valve specimens to identify dual-specificity phosphatase 26 (DUSP26) as an upregulated gene promoting aortic valve calcification in CAVD, subsequently using in vivo mouse and in vitro human VIC studies to confirm that DUSP26 promotes CAVD via upregulation of dipeptidyl peptidase 4 (DPP4) (208). This evidence concerns the gene DUSP26 and congenital bilateral aplasia of vas deferens from CFTR mutation.