NPPB and Arrhythmia: Importantly, the HFA-PEFF algorithm and the 2021 ESC HF guidelines do not add other assessment to the diagnostic pathway in case of AF and those presented two different thresholds depending on the presence of the arrhythmia: LAVI should be >40 mL/m2 to define LA enlargement and NPs levels should be higher to reveal raised LV filling pressures (NT-proBNP should be >365 pg/ml and BNP >105 pg/ml).