TTR and coronary artery disorder: In summary, while different specific etiologies could lead to HFpEF, the most common risk factors and specific causes for HFpEF are moderate-to-severe non-controlled arterial hypertension, moderate-to-severe non-controlled diabetes mellitus, permanent AF, history or presence of severe coronary artery disease (CAD), and to a lesser extent, transthyretin amyloidosis (ATTR), respectively.