Even after adjustment for age, gender, body mass index, diabetes mellitus, dyslipidemia, hypertension, tobacco use, family history, LV-function, NT-proBNP, hs-TnT, and hs-CRP levels, CAD phenotype significantly predicted cardiovascular mortality [Figure 4B; Online Resource 6 (Supplementary Material)]. The gene discussed is NPPB; the disease is diabetes mellitus.