BLM induced alveolar epithelial cell apoptosis through a mitochondrial-dependent pathway, while other studies showed that Fas/FasL pathway is involved in BLM-induced apoptosis and Fas was also overexpressed in alveolar epithelial cells in lung tissues of human idiopathic pulmonary fibrosis [49–51]. The gene discussed is FASLG; the disease is idiopathic pulmonary fibrosis.