Similarly, when comparing the AUC for biomarkers in LN patients, the significant difference between curves was detected when comparing ASC with EGF (p = 3.07E − 08), IL-18 with EGF (p = 9.45E − 06), CRP with EGF (p = 7.08E − 06) and uPA with EGF (0.0004) (Supplementary Table 2), indicating that in LN based on the AUC, EGF as a biomarker is consistently different to several of the other biomarkers analyzed. Here, CRP is linked to lobular neoplasia.