Moreover, considering the multifactorial aspects that contribute to renal diseases, in this study, we analyzed a combination of kidney disease-associated proteins (Lipocalin/NGAL, EGF and uPA), as well as proteins associated with inflammasome activity (ASC and IL-18) and general inflammation (CRP) with the aim of determining their reliability as potential biomarkers of kidney disease, specifically, DKD and LN. This evidence concerns the gene IL18 and diabetic kidney disease.