Moreover, considering the multifactorial aspects that contribute to renal diseases, in this study, we analyzed a combination of kidney disease-associated proteins (Lipocalin/NGAL, EGF and uPA), as well as proteins associated with inflammasome activity (ASC and IL-18) and general inflammation (CRP) with the aim of determining their reliability as potential biomarkers of kidney disease, specifically, DKD and LN. The gene discussed is PLAU; the disease is diabetic kidney disease.