MT-supplied elevated the colitis phenotype, goblet cells number and expression level of MUC2, Villin, Tff3, p-GSK-3β and β-catenin and reduced the DAI score, level of Aeromonas and LPS, and contents of TLR4 and MyD88, and there was no obviously difference between the SD+MT and control groups (P > 0.063). The gene discussed is MYD88; the disease is colitis.