AKIP1 and gastric cancer: In regard to the possible regulatory mechanism of AKIP1 in gastric, it possibly promoted gastric cancer cell invasion and stemness through interacting with other oncology-related factors (such as AKT and NF-kB), or as elucidated in our further experiments, AKIP1 could also regulate the gastric cancer cell functions via upregulating HIF-1α and β-catenin pathways (14, 28–30).