Inhibition of TLR7 expression can alleviate the cytotoxic damage caused by hypoxia and reoxygenation, and the inflammatory response and oxidative stress indexes are significantly reduced, cell apoptosis is reduced, and the degree of hypoxia and reoxygenation damage is reduced, thus providing a new entry point for the clinical treatment of psoriasis. This evidence concerns the gene TLR7 and psoriasis.