The repressive result of CA on MMP-2 and MMP-9 is connected with the obstruction of NF-κB activation, as identified in liver tumor cells stimulated via PMA, leading to a reduction in cancer invasiveness and growth (Chung et al., 2004; Lee et al., 2008; Alam et al., 2017) (Figure 1B). This evidence concerns the gene NFKB1 and cancer.