When better expressed, VEGF causes extravasation of blood from the cancer blood vessels, leading to hepatic bleeding (Zhu et al., 2011; Gu et al., 2016), a significant factor for cancer survival (Zhu et al., 2011; Dhanasekaran et al., 2016; Gu et al., 2016; Klungboonkrong et al., 2017). The gene discussed is VEGFA; the disease is cancer.