TGF-β family proteins, especially TGF-β1, released by injured lung epitheliums, immune cells, and fibrocytes during pulmonary fibrosis, are considered the principal profibrotic cytokines that drives fibrotic responses (Fernandez and Eickelberg, 2012; Martinez et al., 2017; Aschner et al., 2020; Lee et al., 2020). This evidence concerns the gene TGFB1 and pulmonary fibrosis.