Then we observed the influences of CB1R activation on mice with BLM-induced pulmonary fibrosis using the highly selective CB1R agonist ACPA (Figure 1B) to stimulate CB1R. The murine model of pulmonary fibrosis was established by i.t. injection of BLM, and the function of ACPA for pulmonary fibrosis was evaluated by i.p. injection (Figure 1C). The gene discussed is CNR1; the disease is pulmonary fibrosis.