Numerous evidence have demonstrated that CB1R was increased and got involved in the progression of multiple organ fibrosis, including the liver (Patsenker et al., 2011), kidneys (Lecru et al., 2015), heart (Slavic et al., 2013), skin (Lazzerini et al., 2012; Garcia-Gonzalez et al., 2016; Cinar et al., 2017), and pulmonary fibrosis as well (Bronova et al., 2015; Cinar et al., 2017). Here, CNR1 is linked to pulmonary fibrosis.