In addition, RSV can improve STZ-mediated DN symptoms in animals through decreasing the inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) (Koca et al., 2016; Ma et al., 2016). The gene discussed is IL1B; the disease is liver dysplastic nodule.