A set of transcription factors, including Snail, Slug, ZEB1, Twist, play a crucial role in regulation of EMT and drug resistance (Hsu et al., 2010; Xiao et al., 2018; Sale et al., 2019; Yochum et al., 2019), no obviously up-regulation of them was detected in resistant CRC cells. Here, TWIST1 is linked to colorectal carcinoma.