AKT1 and Bloom syndrome: To further clarify whether the PI3K/AKT/GSK-3β/β-catenin signaling pathway participates in EMT in the BLM-induced PF murine model, we examined the effect of LY294002 and XAV-939, potent inhibitors of the PI3K/AKT and Wnt/β-catenin signaling pathways, respectively, on lung fibrosis induced by BLM.