Interestingly, inhibition of the PI3K/AKT and Wnt/β-catenin signaling pathways by LY294002 and XAV-939, respectively, ameliorated the BLM-induced PF and EMT in vivo, and abated DEC1 cDNA-induced EMT in vitro. This evidence concerns the gene BHLHE40 and pemphigus foliaceus.