ACTA1 and pemphigus foliaceus: Interestingly, both LY294002 and XAV-939 ameliorated the degree of lung collagen deposition in the BLM-induced PF murine model (Figures 5A–C) and distinctly reversed the BLM-induced mRNA levels of the fibrosis-related markers, α-SMA, COL1A1, COL1A2, and MMP2 (Figure 5D).