BHLHE40 and Bloom syndrome: In contrast, the levels of p-ser473-AKT, p-ser9-GSK3β and β-catenin were effectively decreased in BLM- induced KO mice, suggesting an involvement of the PI3K/AKT/GSK-3β/β-catenin signaling pathway in BLM-induced PF in vivo and that Dec1 KO inhibits the activation of this BLM-induced pathway (Figures 4A,B).