P2RY12 and migraine disorder: What is more, a recent study found that clopidogrel suppressed nitroglycerin-induced microglial morphological changes (process retraction) and inducible nitric oxide synthase production in the trigeminal nucleus caudalis in chronic migraine mice via inhibiting the microglial P2Y12 receptor activity, which may be a mechanism of relieving migraine attacks, suggesting that both the microglia and platelet should be considered targets of the P2Y12 inhibitor [37].