The pro-inflammatory state caused by the SARS-CoV-2 virus is the main pathophysiological process of the COVID-19, which is characterized by increased levels of serum interleukin-1,6 (IL-1,6) and tumor necrosis factor (TNF), resulting in “cytokine storm” and ARDS (32, 33). Here, IL16 is linked to acute respiratory distress syndrome.