Additionally, some cases of PDB-like syndromes have been attributed to mutations in VCP, TNFRSF11A, TNFRSF11B, HNRNPA2B1, HNRNPA1, ZNF687 and PFN1, most of which are known to involved in the amyotrophic lateral sclerosis (ALS) and nuclear factor kappa B (NF-kB) signaling pathways (26–32). This evidence concerns the gene PFN1 and amyotrophic lateral sclerosis.