Additionally, some cases of PDB-like syndromes have been attributed to mutations in VCP, TNFRSF11A, TNFRSF11B, HNRNPA2B1, HNRNPA1, ZNF687 and PFN1, most of which are known to involved in the amyotrophic lateral sclerosis (ALS) and nuclear factor kappa B (NF-kB) signaling pathways (26–32). Here, NFKB1 is linked to amyotrophic lateral sclerosis.