INS and type 2 diabetes mellitus: The benefits of acutely reducing insulin secretion on β-cell health and function for T2DM gained prominence in the 1970s when Greenwood, Mahler, and Hales suggested that β-cell overstimulation leads to impaired GSIS when they found that diazoxide treatment, a potent inhibitor of insulin secretion, restored β-cell function in T2DM subjects (143).