Mirroring the role of miRNAs in β-cell dedifferentiation due to HF diet, PDX1 Associated lncRNA (PLUTO), which is required for Pdx1 activation (111) and 1810019D21Rik (ROIT) which is required for NK6 Homeobox 1 (Nkx6.1) transcriptional activation were identified as two of the top-most downregulated lncRNAs with HF feeding (38). The gene discussed is PLUT; the disease is hydrops fetalis.