ChREBP and SREBP-1c play a synergic role and regulate the genes expression of glycolytic and lipogenic pathways (61); ChREBP is stimulated by glucose; SREBP-1c is activated by insulin. Both factors regulate FA.synthesis. The upregulation of these factors favors hepatic steatosis, IR and the progression of MetS (62, 63). This evidence concerns the gene MLXIPL and fatty liver disease.