TLR4 is a key receptor of KCs and adipose tissue involved in the activation of the inflammatory response.TLR4 signalling is amplified by OxS and coupled with lipid metabolism (50); CD14 is a co-receptor of TLR4 which facilitates the binding of LPS and the release of cytokines that are dependent of NF-kB (65). TLR4/CD14 signalling favors the progression of NAFLD through NF-kB activation, the release of proinflammatory cytokines (TNF-a,IL6) (65, 66), IR (67, 68) and triglycerides accumulation (69). Here, TLR4 is linked to metabolic dysfunction-associated steatotic liver disease.