Among the 10 genes, ESCO2, HAT1, HDAC1, HDAC2, HDAC4, and HDAC11 are risk factors for HCC, with a risk ratio >1, while KAT8, HDAC6, SIRT3, and SIRT5 are protective factors, with a risk ratio <1. The gene discussed is SIRT3; the disease is hepatocellular carcinoma.