HDAC4 and neoplasm: Targeted inhibition of HDAC4 has been shown to inhibit the growth and metastasis of HCC, and HDAC4 can promote the proliferation, migration and invasion of nasopharyngeal carcinoma cells in vitro, as well as tumor growth and lung metastasis in vivo (Freese et al., 2019; Cheng et al., 2021).