To measure endothelial dysfunction, we documented decreased production of eNOS and KLF2, a zinc finger family of transcription factors and bona-fide master regulator of endothelial maintenance function (Lin et al., 2005), and increased levels of endothelial cell surface von-Willebrand Factor (Panigrahi et al., 2016). This evidence concerns the gene VWF and endothelial dysfunction.