To determine the AML subtypes associated with immune‐related genes and a better prognosis, we used a WCGNA to identify immune genes related to prognosis and established a prognostic risk signature based on seven genes associated with OS (CALR, PSMD3, THBS1, BST2, MPO, OGFR, and CDK6). The gene discussed is PSMD3; the disease is acute myeloid leukemia.