Other classes of SVs have been proposed as part of the established diagnostic criteria of certain cancers, including focal amplification or deletion (EGFR amplification in glioblastoma and CDKN2A/B deletion in IDH mutant astrocytoma [161]) and chromosomal gains and losses (chromosome 7 gain or 10 loss in glioblastoma, 1p and 19q losses in oligodendroglioma (Figure 3B) [175, 176]). The gene discussed is CDKN2A; the disease is glioblastoma.