As shown in Fig. 1A, we firstly analyzed TRPV1 mRNA expression in 8 LUAD paired samples (including tumor tissue and adjacent non-tumor tissue from the same patient) and found that TRPV1 mRNA expression in LUAD tumor tissues was significantly increased compared with non-tumor tissue (P < 0.01; Fig. 1A). Here, TRPV1 is linked to neoplasm.