The trend was validated according to TCGA database, the levels of TRPV1 expression in tumor tissues of LUAD patients were also significantly higher than in normal tissues (P < 0.01), with the median value of 3.81 (inter-quartile range (IQR) 2.59–4.70) in tumor tissues versus 2.59 (IQR 1.59–3.17) in normal tissues (Fig. 1B). This evidence concerns the gene TRPV1 and neoplasm.