AGT and hypertensive disorder: Another Treg-dependent way to protect against hypertension and subsequent damage was demonstrated by Taylor et al. [96] and Majeed et al. [97] who showed that selective Treg expansion by infusion of low-dose IL-2 attenuated BP increases and renal damage in a mouse model of SLE, inhibited aortic collagen remodeling and resulted in vascular stiffening in Ang II-treated mice [96, 97].