Mice with B-cell deficiency due to knockout of the B-cell activating factor receptor (Tnfrsf13c−/− mice) or the transcription factor Myb (c-mybh/h mice), as well as mice treated with anti-CD20 antibody therapy, were protected against Ang II-induced hypertension and showed reduced aortic macrophage infiltration, collagen deposition and vascular stiffening [80, 81]. Here, AGT is linked to hypertensive disorder.