CSF2 and acute myeloid leukemia: We performed bioenergetics assays and observed that the oxygen consumption rate (OCR) was higher, and that the mitochondrial electron transport chain complex I inhibitor IACS-010759 was preferentially cytotoxic in NF1KO and NRASG12D compared to CTR TF-1 cells cultured with GM-CSF, suggesting that RAS−activated AML cells were addicted to mitochondrial oxidative metabolism (Fig. 5D and Supplementalry Fig. 5B).