Meflin+ cells also proliferate to constitute a subset of cancer-associated fibroblasts (CAFs) in the stroma of pancreatic and lung cancer, where Meflin suppresses cancer progression by inhibiting the remodeling of collagen architecture in the stroma and modulating tumor vessel architecture32–34, and colorectal cancer, where Meflin promote BMP signaling35. Here, ISLR is linked to lung cancer.