In the univariate analysis, age, male gender, comorbidities, initial chest X-ray abnormality, absolute neutrophil count (ANC), absolute lymphocyte count (ALC), platelet count, blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), aspartate aminotransferase (AST), albumin, CRP, CPK and LDH were significantly associated with progression to severe pneumonia. The gene discussed is CRP; the disease is susceptibility to pneumonia measurement.