As previously established, genes found upregulated in human mesothelioma development (including Msln and Wt1) or downregulated (including tumor suppressors Nf2 and Bap1) behaved analogously in this mouse model, both in pre-neoplastic lesions and in fully formed tumors when compared to healthy adult mesothelium (Fig. 7B)41,42,128–131. The gene discussed is MSLN; the disease is mesothelioma.