HAND2 and pleural mesothelioma: Analyzing expression levels of HAND2 using qPCR in human pleural mesothelioma (MPM) (n = 36) compared to healthy pleura (n = 4), we observed that individual tumors showed heterogeneous yet consistent upregulation of HAND2, with individual tumors expressing high levels of HAND2 mRNA (p = 0.0596) (Fig. 7D).