The causal role of the MAP6 family of genes in neuronal microtubule stability and synaptic function was established in MAP6-KO mice that exhibited hypo-glutamatergy in hippocampal neurons [79], vesicle depletion in synaptic densities, and impaired LTP and LTD events, which were associated with behavioural differences such as hyperactivity, increased anxiety-like behaviours, and reduced social investigation [80]. Here, MAP6 is linked to Anxiety.