As indicated in Fig. 7a and S1a, lung adenocarcinoma patients with high expression levels of ISG15, MMP1, TRPA1, KRT19, and PLAU (red line) were significantly associated with poor survival rates (log rank P value: 2.3e-07, 0.00034, 0.00037, 0.00057, and 0.023, respectively) as compared to those with low expression (black line). The gene discussed is PLAU; the disease is lung adenocarcinoma.