CNR1 and Insulin resistance: The endogenous endocannabinoid anandamide along with its natural receptor the cannabinoid type 1 receptor (CB1R) are known to be normally involved in hepatic lipogenesis, insulin resistance and glucose intolerance and to be strongly upregulated during normal liver regeneration following partial hepatectomy or major liver injury and confer on the liver a remarkable degree of regenerative capacity [98, 99].