RHOC and posterior cortical atrophy: The results above suggest that in PCa cells, MLN activates two antagonistic Rho-dependent pathways: the activation of RhoA/RhoB stimulates TJSR, inhibits cell migration and induces apoptosis, whereas RhoC mediates prometastatic signaling accompanied by PI3K/AKT/PRK3 activation and promotes MAT, invasion and survival (Fig. 6D).