SCAP and hepatocellular carcinoma: In addition, a negative correlation between SCAP and p-AMPK expression (R2 = 0.2953, P = 0.004) was observed in 12 paired HCC tissues; a similar correlation was also found between SCAP and LC3-II expression (R2 = 0.2894, P = 0.007, Fig. 7D-E).