AR and Familial prostate cancer: Immunohistochemistry (IHC) showed a significant increase in the percentage of Ki-67 positive proliferating cells in Kmt2cSET∆/∆ prostates (Fig. 1g-h, Supplementary Fig. 1g) and clusters of cells highly positive for AR expression, the primary driver of prostate cancer initiation and progression (Fig. 1i-j).