As our murine data show that activation of proliferative signalling pathways occurs concurrently with evasion of p16INK4A-mediated growth arrest, we performed fGSEA on the “core SASP of PICS” gene set and found a significant reduction of this transcriptional signature in KMT2C truncated tumours (Supplementary Fig. 5b), potentially indicating loss of senescence features. Here, CDKN2A is linked to neoplasm.