The relevance of our findings to human patients is supported by the fact that we observe both enrichment of the MYC gene signature and downregulation of CDKN2A, which encodes p16INK4A, in PCa patients with truncation mutations of KMT2C. Remarkably, we found a significant correlation between DFS and truncated KMT2C in patients, demonstrating the prognostic significance of KMT2C mutation status in PCa. This evidence concerns the gene MYC and posterior cortical atrophy.