ADAMTS13 and hemolytic-uremic syndrome: The presence of lesions that are consistently restricted to the kidneys is key to distinguishing HUS from thrombotic thrombocytopenic purpura (TTP), which is another form of thrombotic microangiopathy (TMA) in which brain lesions prevail and are caused by a severe deficiency (< 10%) in the expression of ADAMTS13 (A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13) [1].