VHL and clear cell renal carcinoma: Faronato et al. [23] and Miess et al. [24] thought that the expression of ALOX5 in clear cell renal cell carcinomas deficient in von Hippel-Lindau (VHL) gene was greatly increased, which may be that this kind of cancer cell needs more eicosanoids synthesized through ALOX5 expression to promote local inflammatory response.