The latter, Y RNAs, were initially discovered as components of the Y RNA/SSB/RO60 ribonucleoprotein (RNP) complex termed RoRNP observed in the sera of patients with the autoimmune disorders systemic lupus erythematosus (SLE) and Sjögren’s syndrome [4,5]. This evidence concerns the gene RNPC3 and systemic lupus erythematosus.