To further investigate underlying effects of OTUB1 modulation on tumor cell epithelial-mesenchymal transition (EMT), mRNA and protein expression detection of EMT markers (E-cadherin, Vimentin, N-cadherin) indicated that OTUB1 upregulation was associated with mesenchymal phenotype (Figure 3e-f). The gene discussed is CDH2; the disease is neoplasm.