TNF and hydrops fetalis: In piRNA-6426 overexpression group, the cardiac infarction area (Figure 8A, 8B), SOAT1 protein expression level (Figure 8C, 8D), ROS production and LDH activity in heart tissue homogenate (Figure 8E, 8F, 8O), BNP mRNA (Figure 8M) and the secretion of serum BNP (Figure 8N), inflammatory factors IL-1β and TNF-α (Figure 8G, 8H) were decreased, and the expression level of DNMT3B protein did not change significantly (Figure 8C, 8D), and the systolic (Figure 8L), diastolic and mean arterial pressure of rats were increased compared with the HF group (Figure 8J, 8K).