The potential explanations might be that: (1) declined HDAC4 could promote the progression of atherosclerosis, which consequently resulted in the occurrence of AIS10; (2) decreased HDAC4 might promote arterial stenosis via promoting vascular endothelial cell apoptosis, which was involved in the pathogenesis of AIS.1, 10, 19. Here, HDAC4 is linked to atherosclerosis.