Apart from that, negative association was also found between HDAC4 and disease severity reflected by NIHSS score, which might be caused by that: (1) HDAC4 could alleviate neuron injury through inhibiting neuron cell apoptosis, which suppressed disease severity of AIS12; (2) HDAC4 could alleviate the atherosclerosis lesions via inhibiting vascular endothelial cell damage, consequently decreasing AIS severity.10 The gene discussed is HDAC4; the disease is atherosclerosis.