One of the most prominent of such studies analyzed single-nucleotide polymorphisms (SNPs) in ~60,000 individuals and uncovered CACNA1C, the gene encoding Cav1.2, as a major risk gene for schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder (ADHD) [6]. This evidence concerns the gene CACNA1C and major depressive disorder.