BRD2 and Premature ovarian insufficiency: As indicated by some observations, FSH level below 10 mIU/mL at 12 years and below 6.7 mIU/mL during mid-childhood (between 6 and 10 years) could be seen as an indicator of spontaneous puberty and the possibility of cyclical menstruation, but typically premature ovarian insufficiency within a few years will ensue (123, 129).