SPDEF and asthma: Among the top up-regulated genes were Th2-high asthma biomarkers (CCL26, FCGBP, ITLN1, NOS2), serine and cysteine protease inhibitors (CST1-2/4, SERPINB2/4/10), and secretory transcription factors (SPDEF, FOXA3), while the most down-regulated genes were associated with ciliopathies (CCNO, CFAP161, DNAAF3) or the glutathione S-transferases (GSTA1, GSTA2, GSTA4, GSTA5), of the S100 calcium binding protein family (S100A7-9), the cytochrome P450 monooxygenases (CYP2F1, CYP26B1, CYP2A13), and intracellular vesicle transport genes (RAB37, SEC14L3) (Fig. 6A).