PPARG and hypogonadism: Furthermore, analyzing the effects of omega-3 in the field of fertility, Esmaeili et al. expressed in their review the key role of these micronutrients in the antioxidant and anti-inflammatory pathways driven by PPAR-γ and their related effects on semen quality [44], whereas Noce et al. proposed an interesting supplementary treatment based on omega-3 for the male obesity secondary hypogonadism [45].