HFE and neurodegenerative disease: Although the H63D variant in the HFE gene has been thoroughly described as a risk factor or a genetic modifier in many neurodegenerative diseases (Kim and Connor 2020), in our cohort, we did not find any relationship between the presence of the variant and cognitive or physical abilities, accordingly to previous studies (Berlin et al.2004; Guerreiro et al. 2006; Blázquez et al. 2007; Tisato et al. 2018).