CD4 and familial hypercholesterolemia: We computed three linear multiple regressions one for each dependent variable (MMSE, CDT and SPPB) to analyze the association among neurocognitive/functional scores with genetic variables, HIV-related characteristics (CD4+ T cell count and percentage, nadir of CD4+ T cell count, CD8+ T cell count and zenith of CD8+ T cell count, years on ART and previous virologic failures to ART), clinical history (hypertriglyceridemia, diabetes, hypercholesterolemia, cardiovascular disease, hypertension, liver disease, kidney disease, cancer and BMI) and demographic data (age).