Four recurrent loss-of-function variants were detected in 11 African-descended breast cancer cases, BRCA1:c.3331_3334delCAAG, BRCA1:c.211A>G, BRCA2:c.1389_1390delAG and PALB2:c.1671_1674delTATT (Table 2). The gene discussed is BRCA1; the disease is breast carcinoma.