Among sixteen BRCA1 and BRCA2 pathogenic variants detected in African-descended breast cancer patients in this study, twelve were documented globally, five were found in self-reported African ancestry individuals in non-African countries/regions, one was found in self-reported African ancestry individuals in African countries, eight were previously reported among Brazilians, and one was newly identified (Supplementary Fig. 2). Here, BRCA2 is linked to breast carcinoma.