Also, the release of LSK and progenitor cells from the BM into circulation, previously described to play an essential role for IL-1β-dependent extramedullary hematopoiesis after MI [57], remained unchanged by prasugrel treatment and supports the hypothesis of a direct ADP-dependent and P2Y12 receptor-mediated effect on LSK cells. This evidence concerns the gene IL1B and myocardial infarction.