PDZD7 may act as a modifier gene for USH, but HARS, ABHD12, CIB2, CEP250, CEP78, ESPN, and ARSG could be grouped in a separate syndromic “deaf–blindness” category, to avoid diagnostic pitfalls and misinformation during genetic counseling for Usher syndrome. The gene discussed is PDZD7; the disease is Usher syndrome.