Mutations of MYO7A (Weil et al. 1997), CDH23 (Bork et al. 2001), USH1C (Ouyang et al. 2002), PCDH15 (Ahmed et al. 2002), USH1G (Maria Oonk et al. 2015), and WHRN (Mburu et al. 2003) can cause non-syndromic recessive hearing impairment, and MYO7A variants are also associated with a non-syndromic dominant form of hearing impairment (Liu et al. 1997b). This evidence concerns the gene PCDH15 and Hearing impairment.